December 2 2018

KEYNOTE-57 Findings Demonstrate Converging Medical Oncology and Urology Disciplines

December 15, 2018

Clinical Articles

In this editorial note from Arjun V. Balar, MD, he discusses how the KEYNOTE-57 findings have impacted the treatment landscape for Bacillus Calmette-Guérin—refractory, high-risk nonmuscle invasive bladder cancer.

Immune Checkpoint Success Encourages More Antibody Research

December 18, 2018

Clinical Articles

Over the past 15 years, cancer therapy has been revolutionized through the development and use of antibodies that block T-cell inhibition via immune checkpoint, such as CTLA-4 and PD-1.

Improved OS Observed When Aggressive Radiation, Surgery Is Added to NSCLC Therapy

January 02, 2019

Clinical Articles

Adding aggressive, local radiation or surgery to frontline systemic therapy in patients with stage IV NSCLC whose disease has spread to a limited number of sites resulted in improved overall survival, according to findings presented by Daniel Gomez, MD, and colleagues at the 60th Annual Meeting of the American Society for Radiation Oncology in San Antonio, Texas.

Similar Late AEs Observed With Different Radiation Doses in Breast Cancer

December 14, 2018

Clinical Articles

Women who received 5 fractions of 28.5 Gy over 5 weeks experienced similar adverse events as women who received 50.0 Gy in 25 fractions over 5 weeks, according to findings presented by A. Murray Brunt, MB, BS.

The Future of Prostate Cancer Care: Taking the Fight Early

January 02, 2019

Clinical Articles

The future of prostate cancer treatment will involve using biomarkers to identify which patients will respond to which medications and applying regimens currently in use for patients with advanced disease to men with earlier-stage disease, said Howard I. Scher, MD.

CMS Partially Merges 5-Tier Payment Schedule to Address Care for Complex Patients

December 18, 2018

Clinical Articles

An initiative to streamline the way physicians document Medicare billing for patient evaluation and management was recently resolved and will take effect in the coming year as part of the calendar year 2019 Physician Fee Schedule final rule, the Centers for Medicare & Medicaid Services has announced.

SITC Creates Immunotherapy Guidelines for Metastatic NSCLC

January 02, 2019

Clinical Articles

To assist clinicians in the day-to-day management of their patients, the Society for Immunotherapy of Cancer has developed its first guidelines to help direct immune checkpoint inhibitor treatment of NSCLC.

Expert Sees More Cross-Disciplinary Care in Urothelial Cancer Management

December 24, 2018

Clinical Articles

Since 2016, the FDA has approved 5 immune checkpoint inhibitors to treat urologic cancers. Although that is unquestionably a good thing for patients, the rise of these agents means that the role of the urologist in cancer care is changing, said Noah M. Hahn, MD, during the 2018 Large Urology Group Practice Association Annual Meeting.

For Prostate Cancer, Challenges Continue Over Finding Actionable Mutations

December 25, 2018

Clinical Articles

Up to 30% of men with prostate cancer could meet criteria for genetic evaluation for hereditary disease. The hard part, Sanjeev Kaul, MD, said at the 2018 Large Urology Group Practice Association Annual Meeting, is separating the mutations that are relevant from those that are not.

Expansion Cohorts Guidance Balances Drug Development With Safety, Rigor

December 26, 2018

Clinical Articles

New draft guidelines from the FDA endorse the use of multiple expansion cohorts in first-in-human clinical trials as a means of speeding lifesaving medications to market, but the document warns that the difficulties and dangers of using such complex studies so early in the testing process necessitate unusually careful design and oversight.