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Opinion|Videos|February 27, 2025

Balancing Treatment Intensity and Resistance Mechanisms in First-Line EGFR-mutated NSCLC: Amivantamab + Lazertinib vs Osimertinib Monotherapy

Author(s)Misako Nagasaka, MD, PhD

The panelist discusses how, Healthcare professionals use osimertinib 1L for EGFR-mutated NSCLC, re-testing at progression for resistance mutations. MARIPOSA data refine 1L choices by predicting resistance pathways, guiding optimal sequencing.

Episodes in this series

1 expert in this video

EP. 1 A 47-Year-Old Woman with EGFR-mutated Advanced/Metastatic NSCLC

1 expert in this video

EP. 2 An Academic Perspective to First-Line Treatment Decisions for EGFR-mutated Advanced/Metastatic NSCLC

1 expert in this video

EP. 3 First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Evaluating Amivantamab + Lazertinib and Osimertinib-Based Regimens.

1 expert in this video

EP. 4 Strategies for Adverse Events Management with First-Line Amivantamab + Lazertinib and Osimertinib-Based Regimens in EGFR-mutated Metastatic NSCLC.

1 expert in this video

EP. 5 Balancing Treatment Intensity and Resistance Mechanisms in First-Line EGFR-mutated NSCLC: Amivantamab + Lazertinib vs Osimertinib Monotherapy

1 expert in this video

EP. 6 Future Directions in the Treatment of EGFR-mutated NSCLC: Academic Perspectives and Clinical Pearls.

Video content above is prompted by the following:

What is your sequencing strategy/rationale for 1L and beyond in EGFR-mutated metastatic NSCLC?
When would you re-test for new resistance mutations?
How does recent evidence from MARIPOSA (resistance mechanisms analysis) influence what you would use upfront in 1L treatment?

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