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Opinion|Videos|February 20, 2025

Strategies for Adverse Events Management with First-Line Amivantamab + Lazertinib and Osimertinib-Based Regimens in EGFR-mutated Metastatic NSCLC.

Author(s)Misako Nagasaka, MD, PhD

The panelist discusses how, Healthcare professionals manage distinct toxicities with ami+laz (IRRs, rash) and osi+chemotherapyctx (cytopenias, diarrhea, fatigue). SKIPPirr informs IRR mitigation in ami’s first infusion. Proactive AE strategies include premedication, dose adjustments, supportive care, and monitoring.

Episodes in this series

1 expert in this video

EP. 1 A 47-Year-Old Woman with EGFR-mutated Advanced/Metastatic NSCLC

1 expert in this video

EP. 2 An Academic Perspective to First-Line Treatment Decisions for EGFR-mutated Advanced/Metastatic NSCLC

1 expert in this video

EP. 3 First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Evaluating Amivantamab + Lazertinib and Osimertinib-Based Regimens.

1 expert in this video

EP. 4 Strategies for Adverse Events Management with First-Line Amivantamab + Lazertinib and Osimertinib-Based Regimens in EGFR-mutated Metastatic NSCLC.

1 expert in this video

EP. 5 Balancing Treatment Intensity and Resistance Mechanisms in First-Line EGFR-mutated NSCLC: Amivantamab + Lazertinib vs Osimertinib Monotherapy

1 expert in this video

EP. 6 Future Directions in the Treatment of EGFR-mutated NSCLC: Academic Perspectives and Clinical Pearls.

Video content above is prompted by the following:

What are the toxicity differences you encounter when using i.e. combination ami+laz, chemotherapyosi+ctx?
Please discuss your proactive AE management strategies.
Ami/Laz: How does recent data from SKIPPirr inform your approach to managing IRRs in that first infusion of amivantamab? What proactive AE management strategies do you implement for dermatological toxicities like rash.
chemotherapyOsi/ Ctx: What are proactive AE management strategies for cytopenias, diarrhea and fatigue?

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