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Opinion|Videos|February 20, 2025

First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Evaluating Amivantamab + Lazertinib and Osimertinib-Based Regimens.

Author(s)Misako Nagasaka, MD, PhD

The panelist discusses how, regarding the patient case, she will review the FDA approved options for the patient, including the combination of amivantamab + Lazertinib, osimertinib/chemotherapy, or single agent osimertinib.

Episodes in this series

1 expert in this video

EP. 1 A 47-Year-Old Woman with EGFR-mutated Advanced/Metastatic NSCLC

1 expert in this video

EP. 2 An Academic Perspective to First-Line Treatment Decisions for EGFR-mutated Advanced/Metastatic NSCLC

1 expert in this video

EP. 3 First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Evaluating Amivantamab + Lazertinib and Osimertinib-Based Regimens.

1 expert in this video

EP. 4 Strategies for Adverse Events Management with First-Line Amivantamab + Lazertinib and Osimertinib-Based Regimens in EGFR-mutated Metastatic NSCLC.

1 expert in this video

EP. 5 Balancing Treatment Intensity and Resistance Mechanisms in First-Line EGFR-mutated NSCLC: Amivantamab + Lazertinib vs Osimertinib Monotherapy

1 expert in this video

EP. 6 Future Directions in the Treatment of EGFR-mutated NSCLC: Academic Perspectives and Clinical Pearls.

Video content above is prompted by the following:

Please discuss a treatment approach for the patient case.
Please review the evidence from MARIPOSA (amivantamab + lazertinib) and FLAURA2 (osimertinib/chemotherapy) supporting combination therapy in this setting.

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