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Opinion|Videos|March 13, 2025

Clinical Insights and Patient Considerations for Frontline TKI Therapy in Advanced uHCC

An expert discusses how treatment selection for first-line (1L) tyrosine kinase inhibitor (TKI) therapy in advanced hepatocellular carcinoma (HCC) requires careful evaluation of multiple factors, including liver function (Child-Pugh status), ECOG performance status, tumor burden, and presence of macrovascular invasion or extrahepatic spread. In reviewing individual cases, clinicians assess liver enzyme levels, α-fetoprotein values, radiographic findings, and comorbidities.

Episodes in this series

Video content above is prompted by the following:

  • From your clinical experience, how do you determine which patients are best suited for 1L systemic TKI therapy for advanced unresectable HCC (uHCC)?
  • What factors/details from the patient case (history/diagnostics) are notable?
  • What factors do you consider most when making treatment decisions, and how do those factors influence your treatment approach?
  • How do you determine which patients would benefit from lenvatinib or sorafenib?

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