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Opinion|Videos|March 13, 2025

Clinical Insights and Patient Considerations for Frontline TKI Therapy in Advanced uHCC

Author(s)Amit Mahipal, MD

An expert discusses how treatment selection for first-line (1L) tyrosine kinase inhibitor (TKI) therapy in advanced hepatocellular carcinoma (HCC) requires careful evaluation of multiple factors, including liver function (Child-Pugh status), ECOG performance status, tumor burden, and presence of macrovascular invasion or extrahepatic spread. In reviewing individual cases, clinicians assess liver enzyme levels, α-fetoprotein values, radiographic findings, and comorbidities.

Episodes in this series

1 expert in this video

EP. 1 A 57-Year-Old Woman Diagnosed with Advanced Unresectable Hepatocellular Carcinoma

1 expert in this video

EP. 2 Recent Advances in Front-Line Systemic Therapy for Advanced uHCC

1 expert in this video

EP. 3 Clinical Insights and Patient Considerations for Frontline TKI Therapy in Advanced uHCC

1 expert in this video

EP. 4 Lenvatinib and Depth of Response in Advanced uHCC: Insights From REFLECT

1 expert in this video

EP. 5 Optimizing Frontline TKI Therapy in Advanced uHCC: Managing Adverse Events

1 expert in this video

EP. 6 Academic Perspectives on Systemic Therapy for Advanced uHCC

Video content above is prompted by the following:

From your clinical experience, how do you determine which patients are best suited for 1L systemic TKI therapy for advanced unresectable HCC (uHCC)?
What factors/details from the patient case (history/diagnostics) are notable?
What factors do you consider most when making treatment decisions, and how do those factors influence your treatment approach?
How do you determine which patients would benefit from lenvatinib or sorafenib?

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