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Opinion|Videos|March 13, 2025

Lenvatinib and Depth of Response in Advanced uHCC: Insights From REFLECT

Author(s)Amit Mahipal, MD

An expert discusses how recent analyses from the REFLECT trial in unresectable hepatocellular carcinoma (uHCC) demonstrate that both achieving objective response and greater depth of response correlate with improved survival outcomes. The depth of response serves as a potentially valuable early biomarker for prognosis and treatment decisions, with deeper responses associated with better overall survival among responders.

Episodes in this series

1 expert in this video

EP. 1 A 57-Year-Old Woman Diagnosed with Advanced Unresectable Hepatocellular Carcinoma

1 expert in this video

EP. 2 Recent Advances in Front-Line Systemic Therapy for Advanced uHCC

1 expert in this video

EP. 3 Clinical Insights and Patient Considerations for Frontline TKI Therapy in Advanced uHCC

1 expert in this video

EP. 4 Lenvatinib and Depth of Response in Advanced uHCC: Insights From REFLECT

1 expert in this video

EP. 5 Optimizing Frontline TKI Therapy in Advanced uHCC: Managing Adverse Events

1 expert in this video

EP. 6 Academic Perspectives on Systemic Therapy for Advanced uHCC

Video content above is prompted by the following:

What role do the overall response and depth of response play in guiding treatment decisions for advanced uHCC?
Review recent evidence from REFLECT looking at characterization of tumor response.
Please discuss the clinical implications from the best overall response, depth of response, and overall survival among responders’ data.
What are your thoughts on looking at the depth of response as a marker for clinical outcomes?

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