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Opinion|Videos|March 17, 2025

Clinical Pearls in Intermediate Stage uHCC Management

Author(s)Amit Singal, MD

The panelist discusses, for intermediate-stage unresectable hepatocellular carcinoma (uHCC), key clinical pearls include prioritizing transarterial chemoembolization (TACE) as a first-line therapy, with systemic options for TACE-ineligible patients or progression; consider lenvatinib or atezolizumab plus bevacizumab based on liver function and risk factors. Evaluate treatment success via a radiologic response (mRECIST criteria), AFP levels, and toxicity profiles; modify treatment upon radiologic progression, prohibitive toxicity, or declining performance status.

Episodes in this series

1 expert in this video

EP. 1 Unresectable HCC with Post-TACE Progression

1 expert in this video

EP. 2 Initial Treatment Options for Liver-Confined Unresectable HCC

1 expert in this video

EP. 3 Managing Disease Progression After TACE

1 expert in this video

EP. 4 Role of Systemic Therapy in TACE-Eligible Patients

1 expert in this video

EP. 5 Clinical Pearls in Intermediate Stage uHCC Management

Video content above is prompted by the following:

What remaining clinical pearls can you share regarding systemic therapy treatment approaches for patients with intermediate stage uHCC?
How do you evaluate treatment success over time, and what are the key indicators that guide decisions regarding treatment modifications or sequencing?
What trials are you anticipating that might impact the first-line treatment of uHCC?

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