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Opinion|Videos|March 10, 2025

Role of Systemic Therapy in TACE-Eligible Patients

The panelist discusses how for patients initially eligible for embolization, systemic therapy may be combined with transarterial chemoembolization (TACE) upfront for high-risk disease (ie, large tumor burden, elevated AFP) or reserved for progression after regional therapy in lower-risk cases. Treatment decisions should be individualized based on tumor characteristics, liver function, and patient preferences.

Episodes in this series

Video content above is prompted by the following:

  • What are your perspectives on when and how systemic therapy fits into the treatment paradigm for patients who are initially eligible for embolization?
  • Should systemic therapy be considered upfront in combination with eg, TACE or reserved for progression after regional therapy?
  • Review and discuss recent evidence from the EMERALD-1 and LEAP-012 trials.
  • What are the clinical implications of these data?
  • What patient/nonpatient specific factors would influence these treatment decisions?

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