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Opinion|Videos|March 10, 2025

Role of Systemic Therapy in TACE-Eligible Patients

Author(s)Amit Singal, MD

The panelist discusses how for patients initially eligible for embolization, systemic therapy may be combined with transarterial chemoembolization (TACE) upfront for high-risk disease (ie, large tumor burden, elevated AFP) or reserved for progression after regional therapy in lower-risk cases. Treatment decisions should be individualized based on tumor characteristics, liver function, and patient preferences.

Episodes in this series

1 expert in this video

EP. 1 Unresectable HCC with Post-TACE Progression

1 expert in this video

EP. 2 Initial Treatment Options for Liver-Confined Unresectable HCC

1 expert in this video

EP. 3 Managing Disease Progression After TACE

1 expert in this video

EP. 4 Role of Systemic Therapy in TACE-Eligible Patients

1 expert in this video

EP. 5 Clinical Pearls in Intermediate Stage uHCC Management

Video content above is prompted by the following:

What are your perspectives on when and how systemic therapy fits into the treatment paradigm for patients who are initially eligible for embolization?
Should systemic therapy be considered upfront in combination with eg, TACE or reserved for progression after regional therapy?
Review and discuss recent evidence from the EMERALD-1 and LEAP-012 trials.
What are the clinical implications of these data?
What patient/nonpatient specific factors would influence these treatment decisions?

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