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Opinion|Videos|April 4, 2025

Evolving Treatment Strategies in DLBCL: Real-World Clinical Experience

Author(s)Gilles Salles, MD, PhD, Matthew A. Lunning, DO, FACP

Experts discuss clinical experience with established and emerging treatment approaches in diffuse large B-cell lymphoma (DLBCL), including R-CHOP and polatuzumab-based regimens, and the factors guiding treatment selection for first-line DLBCL, along with observed outcomes across different patient subgroups.

Episodes in this series

EP. 1 Advances in DLBCL Management: Long-Term Treatment Outcomes

EP. 1 Advances in DLBCL Management: Long-Term Treatment Outcomes

EP. 2 Long-Term Outcomes and Treatment Guidelines in DLBCL Management

EP. 2 Long-Term Outcomes and Treatment Guidelines in DLBCL Management

EP. 3 Evolving Treatment Strategies in DLBCL: Real-World Clinical Experience

EP. 3 Evolving Treatment Strategies in DLBCL: Real-World Clinical Experience

EP. 4 DLBCL Subtype Response Patterns: Optimizing Treatment Selection

EP. 4 DLBCL Subtype Response Patterns: Optimizing Treatment Selection

EP. 5 Disease Progression in DLBCL: Management Strategies and Quality-of-Life Considerations

EP. 5 Disease Progression in DLBCL: Management Strategies and Quality-of-Life Considerations

EP. 6 Treatment Decision-Making in DLBCL: Balancing Efficacy, Safety, and Patient Factors

EP. 6 Treatment Decision-Making in DLBCL: Balancing Efficacy, Safety, and Patient Factors

EP. 7 Long-Term Data and Future Directions in First-Line DLBCL Treatment

EP. 7 Long-Term Data and Future Directions in First-Line DLBCL Treatment

Video content above is prompted by the following:

Please share your clinical experience with established and emerging treatment approaches in DLBCL, including R-CHOP and polatuzumab-based regimens.
• When treating first-line DLBCL, what factors guide your selection between various treatment regimens, and what outcomes have you observed across different patient subgroups?

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