What are the relevant findings from her pathology report?
Frits van Rhee, MD, PhD, University of Arkansas for Medical Sciences, says the relevant findings are first of all quite negative. There is no evidence of lymphoma, and the description of the lymph nodes in this patient is consistent with plasmacytic variant of Castleman’s disease. The pathological finding of Castleman’s disease does not make the diagnosis; one must exclude other disorders.
Guess the Diagnosis: Case 1
Lisa B. is a 47-year-old female store owner from St. Louis, with a 10-month history of fatigue, night sweats, and weight loss.
She presents to her PCP with generalized lymphadenopathy, most prominent in the cervical region; there is no polyneuropathy, and patient does not report joint pain. She is referred to a hematologist to rule out lymphoma
Medical history is unremarkable; family history relevant for a mother with systemic lupus erythematous and father who died with prostate cancer at 65 years old
Her physical exam is notable for bilateral cervical lymphadenopathy (1-2 cm), mild splenomegaly, and mild edema