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Opinion|Videos|May 22, 2026

Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

Six-year Sequoia data show zanubrutinib in frontline CLL extends PFS far beyond bendamustine‑rituximab, delaying next treatment.

Episodes in this series

Andrew H. Lipsky,MD, discusses the strong long-term efficacy outcomes with frontline zanubrutinib (Brukinsa) monotherapy in patients with high-risk chronic lymphocytic leukemia and del(17p) alterations, as demonstrated in the 6-year update of the SEQUOIA trial. He emphasizes how these extensive 6-year follow-up data fully elucidate the progression-free survival benefit of zanubrutinib in this high-risk population.

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