Opinion|Videos|May 22, 2026

Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

Author(s)Andrew H. Lipsky, MD

Six-year Sequoia data show zanubrutinib in frontline CLL extends PFS far beyond bendamustine‑rituximab, delaying next treatment.

Episodes in this series

2 experts are featured in this series

EP. 1 SEQUOIA Trial: Long-Term Zanubrutinib Efficacy in CLL

2 experts are featured in this series

EP. 2 SEQUOIA Outcomes in Patients With High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 3 SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL

2 experts are featured in this series

EP. 4 Continuous Vs Fixed Duration Treatment in CLL

2 experts are featured in this series

EP. 5 Dr Stephens on Preferring Continuous BTKi for High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 6 6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

2 experts are featured in this series

EP. 7 Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 8 Zanubrutinib Safety Profile in CLL in Long-Term SEQUOIA Follow-Up

2 experts are featured in this series

EP. 9 Choosing Between Continuous and Fixed Dosing Options in Frontline

2 experts are featured in this series

EP. 10 Comparing BTKi Monotherapies in Frontline

Andrew H. Lipsky,MD, discusses the strong long-term efficacy outcomes with frontline zanubrutinib (Brukinsa) monotherapy in patients with high-risk chronic lymphocytic leukemia and del(17p) alterations, as demonstrated in the 6-year update of the SEQUOIA trial. He emphasizes how these extensive 6-year follow-up data fully elucidate the progression-free survival benefit of zanubrutinib in this high-risk population.

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