Opinion|Videos|April 29, 2026
SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL
Author(s)Tanya Siddiqi, MD
High‑risk del17p CLL patients on single‑agent zanubrutinib show durable progression‑free survival, rivaling outcomes in standard‑risk groups.
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Episodes in this series
Tanya Siddiqi, MD, highlights long-term safety outcomes with first-line zanubrutinib (Brukinsa) in patients with chronic lymphocytic leukemia in the phase 3 SEQUOIA trial. She explains that adverse events with zanubrutinib were manageable and notes that the risk of atrial fibrillation remains low with long-term use of the BTK inhibitor.
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