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Opinion|Videos|April 29, 2026

SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL

Author(s)Tanya Siddiqi, MD

High‑risk del17p CLL patients on single‑agent zanubrutinib show durable progression‑free survival, rivaling outcomes in standard‑risk groups.

Episodes in this series

2 experts are featured in this series

EP. 1 SEQUOIA Trial: Long-Term Zanubrutinib Efficacy in CLL

2 experts are featured in this series

EP. 2 SEQUOIA Outcomes in Patients With High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 3 SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL

2 experts are featured in this series

EP. 4 Continuous Vs Fixed Duration Treatment in CLL

2 experts are featured in this series

EP. 5 Dr Stephens on Preferring Continuous BTKi for High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 6 6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

2 experts are featured in this series

EP. 7 Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 8 Zanubrutinib Safety Profile in CLL in Long-Term SEQUOIA Follow-Up

2 experts are featured in this series

EP. 9 Choosing Between Continuous and Fixed Dosing Options in Frontline

2 experts are featured in this series

EP. 10 Comparing BTKi Monotherapies in Frontline

Tanya Siddiqi, MD, highlights long-term safety outcomes with first-line zanubrutinib (Brukinsa) in patients with chronic lymphocytic leukemia in the phase 3 SEQUOIA trial. She explains that adverse events with zanubrutinib were manageable and notes that the risk of atrial fibrillation remains low with long-term use of the BTK inhibitor.

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