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Opinion|Videos|May 22, 2026

Choosing Between Continuous and Fixed Dosing Options in Frontline

Six-year data show zanubrutinib remains well tolerated, with rare atrial fibrillation, low bleeding, and no new safety concerns.

Episodes in this series

In the SEQUOIA trial, the BTK inhibitor zanubrutinib was delivered as a continuous dose in frontline chronic lymphocytic leukemia. Andrew H. Lipsky,MD, discusses the potential lifestyle benefits for patients of a continuous dosing approach. He describes BTK monotherapy as the “most simplistic option that we can offer our patients in frontline CLL” at the current time.

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