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Opinion|Videos|May 22, 2026

Choosing Between Continuous and Fixed Dosing Options in Frontline

Author(s)Andrew H. Lipsky, MD

Six-year data show zanubrutinib remains well tolerated, with rare atrial fibrillation, low bleeding, and no new safety concerns.

Episodes in this series

2 experts are featured in this series

EP. 1 SEQUOIA Trial: Long-Term Zanubrutinib Efficacy in CLL

2 experts are featured in this series

EP. 2 SEQUOIA Outcomes in Patients With High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 3 SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL

2 experts are featured in this series

EP. 4 Continuous Vs Fixed Duration Treatment in CLL

2 experts are featured in this series

EP. 5 Dr Stephens on Preferring Continuous BTKi for High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 6 6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

2 experts are featured in this series

EP. 7 Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 8 Zanubrutinib Safety Profile in CLL in Long-Term SEQUOIA Follow-Up

2 experts are featured in this series

EP. 9 Choosing Between Continuous and Fixed Dosing Options in Frontline

2 experts are featured in this series

EP. 10 Comparing BTKi Monotherapies in Frontline

In the SEQUOIA trial, the BTK inhibitor zanubrutinib was delivered as a continuous dose in frontline chronic lymphocytic leukemia. Andrew H. Lipsky,MD, discusses the potential lifestyle benefits for patients of a continuous dosing approach. He describes BTK monotherapy as the “most simplistic option that we can offer our patients in frontline CLL” at the current time.

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