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Opinion|Videos|May 22, 2026

6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

For high-risk CLL, experts favor continuous BTK inhibitors and weigh venetoclax visit demands to match frontline therapy to lifestyle.

Episodes in this series

Andrew H. Lipsky,MD, highlights 6-year follow-up data from the phase 3 SEQUOIA trial (NCT03336333) showing that the BTK inhibitor zanubrutinib (Brukinsa) sustained a robust progression-free survival benefit vs chemoimmunotherapy in patients with chronic lymphocytic leukemia. Of note, the study included a dedicated cohort of high-risk del(17p) patients who were all treated with zanubrutinib monotherapy, and the BTK inhibitor was effective in this patient population.

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