Opinion|Videos|May 22, 2026
6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL
Author(s)Andrew H. Lipsky, MD
For high-risk CLL, experts favor continuous BTK inhibitors and weigh venetoclax visit demands to match frontline therapy to lifestyle.
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Andrew H. Lipsky,MD, highlights 6-year follow-up data from the phase 3 SEQUOIA trial (NCT03336333) showing that the BTK inhibitor zanubrutinib (Brukinsa) sustained a robust progression-free survival benefit vs chemoimmunotherapy in patients with chronic lymphocytic leukemia. Of note, the study included a dedicated cohort of high-risk del(17p) patients who were all treated with zanubrutinib monotherapy, and the BTK inhibitor was effective in this patient population.
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