Opinion|Videos|May 22, 2026

6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

Author(s)Andrew H. Lipsky, MD

For high-risk CLL, experts favor continuous BTK inhibitors and weigh venetoclax visit demands to match frontline therapy to lifestyle.

Episodes in this series

2 experts are featured in this series

EP. 1 SEQUOIA Trial: Long-Term Zanubrutinib Efficacy in CLL

2 experts are featured in this series

EP. 2 SEQUOIA Outcomes in Patients With High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 3 SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL

2 experts are featured in this series

EP. 4 Continuous Vs Fixed Duration Treatment in CLL

2 experts are featured in this series

EP. 5 Dr Stephens on Preferring Continuous BTKi for High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 6 6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

2 experts are featured in this series

EP. 7 Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 8 Zanubrutinib Safety Profile in CLL in Long-Term SEQUOIA Follow-Up

2 experts are featured in this series

EP. 9 Choosing Between Continuous and Fixed Dosing Options in Frontline

2 experts are featured in this series

EP. 10 Comparing BTKi Monotherapies in Frontline

Andrew H. Lipsky,MD, highlights 6-year follow-up data from the phase 3 SEQUOIA trial (NCT03336333) showing that the BTK inhibitor zanubrutinib (Brukinsa) sustained a robust progression-free survival benefit vs chemoimmunotherapy in patients with chronic lymphocytic leukemia. Of note, the study included a dedicated cohort of high-risk del(17p) patients who were all treated with zanubrutinib monotherapy, and the BTK inhibitor was effective in this patient population.

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