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Opinion|Videos|April 29, 2026

SEQUOIA Trial: Long-Term Zanubrutinib Efficacy in CLL

Author(s)Tanya Siddiqi, MD

Six-year data show continuous zanubrutinib keeps CLL controlled longer than bendamustine-rituximab, including high-risk del17p/TP53 patients.

Episodes in this series

2 experts are featured in this series

EP. 1 SEQUOIA Trial: Long-Term Zanubrutinib Efficacy in CLL

2 experts are featured in this series

EP. 2 SEQUOIA Outcomes in Patients With High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 3 SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL

2 experts are featured in this series

EP. 4 Continuous Vs Fixed Duration Treatment in CLL

2 experts are featured in this series

EP. 5 Dr Stephens on Preferring Continuous BTKi for High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 6 6-Year SEQUOIA Data With Zanubrutinib in Frontline CLL

2 experts are featured in this series

EP. 7 Frontline Zanubrutinib Efficacy in High-Risk Del(17p) CLL

2 experts are featured in this series

EP. 8 Zanubrutinib Safety Profile in CLL in Long-Term SEQUOIA Follow-Up

2 experts are featured in this series

EP. 9 Choosing Between Continuous and Fixed Dosing Options in Frontline

2 experts are featured in this series

EP. 10 Comparing BTKi Monotherapies in Frontline

Tanya Siddiqi, MD,discusses long term follow-up of 6 years for the phase 3 SEQUOIA trial, which showed a sustained progression-free survival benefit with the BTK inhibitor zanubrutinib (Brukinsa) in patients with chronic lymphocytic leukemia. Notably, the study included both lower-risk patients without del(17p) and high-risk patients with del(17p).

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