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Opinion|Videos|November 7, 2025

Future Directions in ES-SCLC and Closing Remarks

Author(s)Melissa Johnson, MD

A panelist discusses how novel bispecifics and ADCs signal a more hopeful future for ES-SCLC management.

Episodes in this series

An expert is featured in this series.

EP. 1 Relapsed Extensive-Stage Small Cell Lung Cancer – Segment Summaries

An expert is featured in this series.

EP. 2 Prognostic Factors and Second-Line Treatment Options in ES-SCLC

An expert is featured in this series.

EP. 3 Efficacy and Impact of Tarlatamab on Clinical Practice

An expert is featured in this series.

EP. 4 Safety Profiles and CRS Management in ES-SCLC

An expert is featured in this series.

EP. 5 Lurbinectedin and Tarlatamab in ES-SCLC

An expert is featured in this series.

EP. 6 Future Directions in ES-SCLC and Closing Remarks

A panelist discusses how the therapeutic landscape of extensive-stage small cell lung cancer (ES-SCLC) is rapidly expanding, with DLL3 bispecifics, antibody-drug conjugates (ADCs), and novel immunotherapy combinations showing promise. They compare emerging agents such as ifinatamab deruxtecan and sacituzumab govitecan, envisioning future sequencing and combination strategies.

A panelist discusses how integration of multiple targeted mechanisms may enhance durability of response and extend patient benefit.

A panelist discusses how ongoing research and innovation continue to drive optimism for improved survival outcomes in this historically difficult-to-treat disease.

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