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Opinion|Videos|October 31, 2025

Safety Profiles and CRS Management in ES-SCLC

Author(s)Melissa Johnson, MD

A panelist discusses how proactive management of CRS and ICANS supports safe community use of DLL3-targeted therapy.

Episodes in this series

An expert is featured in this series.

EP. 1 Relapsed Extensive-Stage Small Cell Lung Cancer – Segment Summaries

An expert is featured in this series.

EP. 2 Prognostic Factors and Second-Line Treatment Options in ES-SCLC

An expert is featured in this series.

EP. 3 Efficacy and Impact of Tarlatamab on Clinical Practice

An expert is featured in this series.

EP. 4 Safety Profiles and CRS Management in ES-SCLC

An expert is featured in this series.

EP. 5 Lurbinectedin and Tarlatamab in ES-SCLC

An expert is featured in this series.

EP. 6 Future Directions in ES-SCLC and Closing Remarks

A panelist discusses how managing cytokine release syndrome (CRS) and immune cell–associated neurotoxicity (ICANS) is essential for safely delivering DLL3-targeted therapy. They share best practices for prevention and early recognition, emphasizing the use of step-up dosing, tocilizumab protocols, and patient monitoring.

A panelist discusses how tarlatamab’s lower incidence of severe adverse events compared to chemotherapy supports its favorable risk-benefit profile. They recommend structured monitoring and team coordination to mitigate risk in community settings.

A panelist discusses how clinician education and preparedness are key to ensuring safe adoption of bispecific immunotherapies in routine care.

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