Opinion|Videos|January 24, 2025

IMROZ Data Highlights and Clinical Insights Into Quadruplet CD38-Containing Regimens in Transplant-Ineligible NDMM

Author(s)Rafael Fonseca, MD, Binod Dhakal, MD, MS, Doris K. Hansen, MD

Panelists discuss how the IMROZ trial demonstrated improved outcomes with quadruplet therapy combining daratumumab, lenalidomide, melphalan, and prednisone in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM), highlighting its potential as a new treatment standard.

Episodes in this series

4 experts are featured in this series.

EP. 1 Expert Insights: Navigating the Evolving Treatment Landscape in NDMM

4 experts are featured in this series.

EP. 2 Clinical Insights: Starting with a Patient Case 1: 74yo 74-Year-Old Patient With NDMM Transplant- Ineligible NDMM

4 experts are featured in this series.

EP. 3 Evaluating Guideline-Recommended Treatment Options for Transplant-Ineligible or Transplant-Deferred NDMM

4 experts are featured in this series.

EP. 4 Diving Deep Into the CEPHEUS Trial: Subcutaneous Dara-VRd vs VRd in Transplant-Ineligible or Transplant-Deferred NDMM

4 experts are featured in this series.

EP. 5 IMROZ Data Highlights and Clinical Insights Into Quadruplet CD38-Containing Regimens in Transplant-Ineligible NDMM

4 experts are featured in this series.

EP. 6 Patient Case 2: A 65-Year-Old Patient With Standard-Risk, Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 7 Selecting Among Guideline Recommended Treatment Options in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 8 PERSEUS Trial Highlights: Dara-VRd vs VRd in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 9 Clinical Perspectives: Question to Start Asking Is Who Not to Give Quadruplet CD38-Containing Regimens in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 10 Exploring Maintenance Strategies Post Autologous Transplant

4 experts are featured in this series.

EP. 11 Patient Case 4: A 58-Year-Old Woman With High-Risk MM Post HSCT With Progressive Disease—What Are Next Steps?

4 experts are featured in this series.

EP. 12 Patient Case 4: A 38-Year-Old Woman With Functional High-Risk MM With Progressive Disease at Day 60 Post ASCT—Next Treatment Approaches

4 experts are featured in this series.

EP. 13 Strategies to Overcome CAR T Roadblocks in the Real-World Practice Setting

4 experts are featured in this series.

EP. 14 CARTITUDE-4 Highlights: Cilta-Cel vs Standard of Care in R/R MM

4 experts are featured in this series.

EP. 15 CARTITUDE-4: Navigating Late CAR-T Toxicities

4 experts are featured in this series.

EP. 16 Patient Case 5: A 66-Year-Old Patient With R/R MM With Relapse Less Than 2 Years Post ASCT—Next Steps

4 experts are featured in this series.

EP. 17 KarMMa-3 Highlights: Ide-Cel vs Standard Regimens in Triple-Class– Exposed RRMM

4 experts are featured in this series.

EP. 18 KarMMa-3 Trial: Additional Insights From Ide-Cel in RRMM

4 experts are featured in this series.

EP. 19 Future Outlooks for CAR T in Early R/R Multiple Myeloma

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