What are the third-line options available to prolong life in this patient?
In metastatic triple negative breast cancer, not all patients live long enough to receive third-line treatment. When patients do, we certainly want to chose a regimen that has been proven to prolong survival. After patients have received a taxane and anthracycline, and they need a third-line therapy, the only regimen we have that has been shown to improve survival is eribulin.
Triple Negative Breast Cancer: Case 2
Connie C is a 56-year-old television producer for a local news station, her medical history is unremarkable for any chronic conditions.
In September of 2014, after presenting to her PCP with a palpable breast mass and fatigue of several months’ duration she underwent a left mammogram revealing a large breast mass.
In February of 2015, she returns with increasing fatigue and back pain; her CT scan shows progression of the hepatic lesions, and bone scan shows new lesions in the T4 and T5 vertebra. At the time of progression, her ECOG performance status (PS) is 1.
In June of 2015, she returns for follow up with worsening back pain and intermittent dyspnea. Her CT scan at the time of progression shows the bone lesions worsening and several new bilateral pulmonary lesions.