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Opinion|Videos|June 29, 2026

Long-Term Data for Continuous BTKi in Frontline CLL

Author(s)Daniel Ermann, MD

Daniel Ermann, MD, discusses what long-term clinical trial and real-world data have shown about the benefits and durability of continuous BTK inhibitor therapy in the frontline treatment of chronic lymphocytic leukemia.

Episodes in this series

EP. 1 Long-Term Data for Continuous BTKi in Frontline CLL

EP. 1 Long-Term Data for Continuous BTKi in Frontline CLL

EP. 2 Treatment Considerations With Newly Diagnosed Older CLL Patients

EP. 2 Treatment Considerations With Newly Diagnosed Older CLL Patients

EP. 3 Long-Term Follow-Up With Zanubrutinib Across CLL Patient Populations

EP. 3 Long-Term Follow-Up With Zanubrutinib Across CLL Patient Populations

EP. 4 Significance of Having Both Real-World and Clinical Trial Data for Frontline BTKi in CLL

EP. 4 Significance of Having Both Real-World and Clinical Trial Data for Frontline BTKi in CLL

EP. 5 Discussions With Older CLL Patients on Frontline BTKi Treatment

EP. 5 Discussions With Older CLL Patients on Frontline BTKi Treatment

EP. 6 Advice for Community Oncologists on Optimizing Frontline BTKi for CLL

EP. 6 Advice for Community Oncologists on Optimizing Frontline BTKi for CLL

EP. 7 Real-World Medicare Database Outcomes With BTKi in Frontline CLL

EP. 7 Real-World Medicare Database Outcomes With BTKi in Frontline CLL

EP. 8 Impact of Real-World Data on BTKi Treatment Selection in Frontline CLL

EP. 8 Impact of Real-World Data on BTKi Treatment Selection in Frontline CLL

EP. 9 Real World Studies Show Frontline BTKi Benefit in More Representative CLL Populations

EP. 9 Real World Studies Show Frontline BTKi Benefit in More Representative CLL Populations

EP. 10 Treatment Sequencing in Elderly Patients With CLL

EP. 10 Treatment Sequencing in Elderly Patients With CLL

Daniel Ermann, MD, discusses what long-term clinical trial and real-world data have shown about the benefits and durability of continuous BTK inhibitor therapy in the frontline treatment of chronic lymphocytic leukemia. In particular, he highlights how real-world data are starting to draw distinctions in efficacy and safety outcomes among the second-generation BTK inhibitors.

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