Monoclonal Antibodies in Relapsed Multiple Myeloma with Ola Landgren, MD, PhD: Case 1
Monoclonal Antibodies in Relapsed Multiple Myeloma with Ola Landgren, MD, PhD
Case Scenario 1:
- The patient is a 61-year-old male who was diagnosed with ISS stage II MM.
- Performance status 0.
- At diagnosis bone marrow shows 40% light chain restricted plasma cells, FISH cytogenetics show hyperdiploid phenotype.
- M-spike of 3.2 g/dL IgG kappa, serum free light chains kappa 60 mg/dL, lambda 1.5 mg/dL, ratio=40
- Bloodwork show beta-2 microglobulin=4.2 mg/dL, Hg=8.2 g/dL, creatinine=0.9 mg/dL.
- PET/CT shows multiple focal bone lesions in upper and lower extremities and in L2 and L3.Bone lesions have increased SUVs.
- Based on these data and diagnosis of standard risk he was started on lenalidomide, bortezomib, and dexamethasone (RVD) induction.
- He achieved a partial response with RVD.
- He then had an autologous stem cell transplantation and achieved MRD negativity.
- He was started on lenalidomide maintenance of 10 mg.
- Patient was experiencing back pain, loss of appetite and weight loss.
- Blood work show beta-2 microglobulin=4.0 mg/dL, Hg=9 g/dL, creatinine=1.5 mg/dL.
- M-spike is 0.5 g/dL, serum free light chains kappa 60 mg/dL, lambda 0.6 mg/dL, ratio=10.
- Performance status 1.
- Based on these criteria he was diagnosed with standard-risk multiple myeloma.
- He was started on daratumumab, bortezomib, and dexamethasone.