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Opinion|Videos|March 11, 2025

Sequencing Multiple Lines of Therapy in Metastatic RCC

Author(s)Pedro Barata, MD, MSc, FACP

An expert discusses using sequence therapies based on disease progression, patient factors, and resistance mechanisms. After a first-line tyrosine kinase inhibitor plus immune checkpoint inhibitor (TKI + ICI) regimen, preferred subsequent-line options include alternative TKIs, chemotherapy, or combination strategies, tailored to patient response and tolerability.

Episodes in this series

1 expert in this video

EP. 1 Case 2: Patient With Relapsed/Recurrent Metastatic RCC

1 expert in this video

EP. 2 Treatment Goals for Transitioning From 2L to 3L mRCC

1 expert in this video

EP. 3 Third-Line Treatments and Current Practice Guidelines in Advanced RCC

1 expert in this video

EP. 4 A Review of Current and Emerging Clinical Data for 3L mRCC

1 expert in this video

EP. 5 Individualized Approaches in 3L Treatment Selection for mRCC

1 expert in this video

EP. 6 Sequencing Multiple Lines of Therapy in Metastatic RCC

1 expert in this video

EP. 7 Navigating TKI Toxicities: Expert Perspectives and Clinical Distinctions

Video content above is prompted by the following:

How are you sequencing these agents through multiple lines of therapy?
Thinking beyond the patient case just reviewed, please discuss your preferred subsequent line after a first-line TKI + ICI regimen.
Would you have followed the sequence of therapies used for the patient described in this case?

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