
Opinion|Videos|February 27, 2025
Treatment Goals for Transitioning From 2L to 3L mRCC
Author(s)Pedro Barata, MD, MSc, FACP
An expert discusses how, in third line (3L) therapy, goals shift from optimal disease control to managing treatment-resistant disease while preserving quality of life. Unlike 2L therapy where significant disease control is still expected, 3L aims for modest clinical benefit, symptomatic relief, and stabilizing disease progression. Treatment choices now heavily prioritize tolerability, patient preferences, and palliative considerations.
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Episodes in this series

Video content above is prompted by the following:
- What are the goals of therapy going into 3L?
- Do they differ from 2L?
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