Supportive Care With Frontline Therapy in Newly Diagnosed Multiple Myeloma

In this segment, Dr. Luciano Costa provides practical considerations for managing patients with newly diagnosed multiple myeloma receiving frontline quadruplet therapy. He emphasizes the importance of viewing quadruplet therapy as an option for patients who can tolerate it while recognizing that treatment decisions should extend beyond the selection and dosing of anticancer agents. Dr. Costa highlights the importance of supportive care, particularly in older and more vulnerable patients, and discusses the need for appropriate prophylactic measures during treatment. He emphasizes proactive management of thrombotic risk and infection prevention, as well as close attention to early signs of infection. The discussion underscores the importance of supportive care during the first several months of frontline treatment, when complications may substantially affect a patient's clinical course. Dr. Costa's perspective reinforces the need to balance treatment intensity with patient-specific tolerability and to incorporate supportive care measures alongside disease-directed therapy.