The Mechanism of Action of Trastuzumab

October 20, 2014
Ruth M. O’Regan, MD

Ruth M. O’Regan, MD, director, Translational Breast Cancer Research, professor, hematology and oncology, medical oncology, Winship Cancer Institute, Emory University, discusses the mechanism of action of trastuzumab.

Clinical Pearls

Ruth M. O’Regan, MD, director, Translational Breast Cancer Research, professor, hematology and oncology, medical oncology, Winship Cancer Institute, Emory University, discusses the mechanism of action of trastuzumab.

  • Trastuzumab has an effect on phosphorylation cascades that drive cancers, but that is not believed to be its main mechanism of action. Its effect on the immune system seems to be important.
  • There is a need for a better understanding of trastuzumab’s resistance mechanisms.