Thyroid Hormone Receptor and Runx2 Expression in Thyroid Cancer Cells

References

Frances Carr, PhD, professor, Department of Pharmacology, The University of Vermont, discusses the relationship between the thyroid hormone receptor and Runx2 expression in thyroid cancer cells.

• The thyroid hormone receptor is a possible tumor suppressor.
• Studies have shown that Runx2 may be a tumor promoter in papillary thyroid cancer.
• An inverse relationship was seen between thyroid hormone receptor expression and Runx2.
• This relationship is being explored and could have therapeutic implications in the future.

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