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|Videos|January 9, 2014
Tivantinib and Regorafenib for the Treatment of Liver Cancer
Author(s)Richard S. Finn, MD
Richard S. Finn, MD, associate professor of medicine, Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine at UCLA, discusses the use of tivantinib and regorafenib for the treatment of patients with liver cancer.
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Clinical Pearls
Richard S. Finn, MD, associate professor of medicine, Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine at UCLA, discusses the use of tivantinib and regorafenib for the treatment of patients with liver cancer.
- Tivantinib is in phase III development for liver cancer
- A phase II study comparing tivantinib to placebo showed no dramatic benefit in all-comers
- An analysis showed high MET expression was associated with worse prognosis, and high MET patients saw benefit from tivantinib versus low MET
- Regorafenib has shown activity in colorectal cancer and GIST
- A phase II study of regorafenib demonstrated provocative survival data for patients who have progressed on sorafenib
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