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Opinion|Videos|March 14, 2025

Treatment Insights From RESPONSE: Ruxolitinib Therapy in Hydroxyurea-Resistant/Intolerant Disease

An expert discusses how the positive efficacy findings from the phase 3 RESPONSE trial, showing high rates of hematocrit control and spleen response with ruxolitinib vs standard therapy in hydroxyurea-resistant/intolerant polycythemia vera (PV), have enhanced the treatment approach for patients with inadequate response to hydroxyurea.

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Video content above is prompted by the following:

The phase 3 RESPONSE trial findings showed high rates of hematocrit control and spleen response with ruxolitinib vs standard therapy in hydroxyurea-resistant/intolerant PV (Kiladjian et al. 2020 Lancet Haematol). How have these positive efficacy findings enhanced your treatment approach for patients with inadequate response to hydroxyurea?

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