|Videos|November 7, 2014

Using the LGR5 Protein as a Biomarker in Thyroid Cancer

Brittany N. Bohinc, MD, Division of Endocrinology, Duke University, discusses the potential to use LGR5 as a biomarker in papillary thyroid cancer.

Clinical Pearls

Brittany N. Bohinc, MD, Division of Endocrinology, Duke University, discusses the potential to use LGR5 as a biomarker in papillary thyroid cancer.

LGR5 is a protein that marks cancer stems cells. It is known to be important in colorectal cancer and gastric cancer.
Using two methods, researchers found that LGR5 was highly expressed in papillary thyroid cancer.
LGR5 in thyroid cancer is associated with lymph node number, lymph node metastases, tumor size, T stage, N stage, extrathyroidal extension, lymphovascular invasion, and macroscopic extension.
LGR5 could be used as a biomarker for novel therapeutics or risk stratification for surgery.

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Using the LGR5 Protein as a Biomarker in Thyroid Cancer

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