Updates in Use of ARIs and Ra-223 for Metastatic Castration-Resistant Prostate Cancer

An expert discusses the case of a patient with metastatic castration-resistant prostate cancer (CRPC) who progressed after treatment with androgen receptor pathway inhibitors (ARPI) and docetaxel for localized prostate cancer.

An expert discusses the therapeutic options included in the NCCN guidelines for metastatic castration-resistant prostate cancer, such as abiraterone (ABI) based on COU-AA-301 and enzalutamide (ENZA) based on AFFIRM.

An expert discusses the design and objectives of the PEACE-3 study, which investigates the combination of enzalutamide and radium-223 for ARPI-naïve metastatic castration-resistant prostate cancer (mCRPC).

An expert discusses the design and objectives of the Phase 3 PEACE-3 study, which evaluates the combination of enzalutamide (ENZA) and radium-223 (Ra-223) for ARPI-naïve metastatic castration-resistant prostate cancer (mCRPC).

An expert discusses the key efficacy findings from the PEACE-3 study, including results on radiographic progression-free survival (rPFS) and overall survival (OS), and offers insights on how to interpret and apply these results in clinical practice.

An expert discusses the safety findings from the PEACE-3 study, highlighting the adverse events associated with the combination of enzalutamide and radium-223 in ARPI-naïve metastatic castration-resistant prostate cancer.

An expert discusses alternative treatment options for a symptomatic patient with metastatic castration-resistant prostate cancer (mCRPC) and highlights the caveats around the data from the Phase 3 ALSYMPCA study of radium-223, including its conduct in an era prior to the introduction of abiraterone (ABI) and enzalutamide (ENZA).

An expert discusses what has been learned about the use of bone-protecting agents and bone density scans for patients receiving an androgen receptor pathway inhibitor (ARPI) in combination with radium-223, based on data from the Phase 3 PEACE-3 study (Enza + Ra-223) and the Phase 3 ERA-223 study (AAP + Ra-223).

An expert discusses other ongoing investigations exploring radium-223-based combinations for the treatment of metastatic castration-resistant prostate cancer, highlighting key studies and their potential impact on clinical practice.

An expert discusses other ongoing investigations exploring radium-223-based combinations for the treatment of metastatic castration-resistant prostate cancer, highlighting key studies and their potential impact on clinical practice.