Protecting bone health for patients receiving Ra-223 + ARPI combination

An expert discusses what has been learned about the use of bone-protecting agents and bone density scans for patients receiving an androgen receptor pathway inhibitor (ARPI) in combination with radium-223, based on data from the Phase 3 PEACE-3 study (Enza + Ra-223) and the Phase 3 ERA-223 study (AAP + Ra-223).

EP: 1.Case presentation: Patient with metastatic CRPC after ARPI and docetaxel for localized PC

EP: 2.Therapeutic options for a patient with mCRPC after ADT + docetaxel

EP: 3.PEACE-3 study of enzalutamide + Ra-223 for ARPI-naïve mCRPC: Design and objectives

EP: 4.PEACE-3 Study Results: Study Population & Disposition

EP: 5.PEACE-3 Study Results: Efficacy

EP: 6.PEACE-3 Study Results: Safety

EP: 7.How would therapeutic options change if this patient was asymptomatic?

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EP: 8.Protecting bone health for patients receiving Ra-223 + ARPI combination

EP: 9.Ongoing studies of Ra-223–based combinations

EP: 10.Ongoing studies of Ra- 223–based combinations

• What has been learned about use of bone protecting agents and bone density scans for patients receiving an ARPI in combination with Ra-223?
  • Phase 3 PEACE 3 – Enza + Ra-223
  • Phase 3 ERA 223, AAP + Ra-223

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