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Opinion|Videos|February 27, 2025

PEACE-3 Study Results: Study Population & Disposition

Author(s)Abhishek Tripathi, MD

An expert discusses the design and objectives of the Phase 3 PEACE-3 study, which evaluates the combination of enzalutamide (ENZA) and radium-223 (Ra-223) for ARPI-naïve metastatic castration-resistant prostate cancer (mCRPC).

Episodes in this series

EP. 1 Case presentation: Patient with metastatic CRPC after ARPI and docetaxel for localized PC

EP. 1 Case presentation: Patient with metastatic CRPC after ARPI and docetaxel for localized PC

EP. 2 Therapeutic options for a patient with mCRPC after ADT + docetaxel

EP. 2 Therapeutic options for a patient with mCRPC after ADT + docetaxel

EP. 3 PEACE-3 study of enzalutamide + Ra-223 for ARPI-naïve mCRPC: Design and objectives

EP. 3 PEACE-3 study of enzalutamide + Ra-223 for ARPI-naïve mCRPC: Design and objectives

EP. 4 PEACE-3 Study Results: Study Population & Disposition

EP. 4 PEACE-3 Study Results: Study Population & Disposition

EP. 5 PEACE-3 Study Results: Efficacy

EP. 5 PEACE-3 Study Results: Efficacy

EP. 6 PEACE-3 Study Results: Safety

EP. 6 PEACE-3 Study Results: Safety

EP. 7 How would therapeutic options change if this patient was asymptomatic?

EP. 7 How would therapeutic options change if this patient was asymptomatic?

EP. 8 Protecting bone health for patients receiving Ra-223 + ARPI combination

EP. 8 Protecting bone health for patients receiving Ra-223 + ARPI combination

EP. 9 Ongoing studies of Ra-223–based combinations

EP. 9 Ongoing studies of Ra-223–based combinations

EP. 10 Ongoing studies of Ra- 223–based combinations

EP. 10 Ongoing studies of Ra- 223–based combinations

Please review the design and objectives of the phase 3 PEACE 3 study of ENZA + Ra-223 for ARPI-naïve mCRPC.

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