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Opinion|Videos|March 13, 2025

How would therapeutic options change if this patient was asymptomatic?

Author(s)Abhishek Tripathi, MD

An expert discusses alternative treatment options for a symptomatic patient with metastatic castration-resistant prostate cancer (mCRPC) and highlights the caveats around the data from the Phase 3 ALSYMPCA study of radium-223, including its conduct in an era prior to the introduction of abiraterone (ABI) and enzalutamide (ENZA).

Episodes in this series

EP. 1 Case presentation: Patient with metastatic CRPC after ARPI and docetaxel for localized PC

EP. 1 Case presentation: Patient with metastatic CRPC after ARPI and docetaxel for localized PC

EP. 2 Therapeutic options for a patient with mCRPC after ADT + docetaxel

EP. 2 Therapeutic options for a patient with mCRPC after ADT + docetaxel

EP. 3 PEACE-3 study of enzalutamide + Ra-223 for ARPI-naïve mCRPC: Design and objectives

EP. 3 PEACE-3 study of enzalutamide + Ra-223 for ARPI-naïve mCRPC: Design and objectives

EP. 4 PEACE-3 Study Results: Study Population & Disposition

EP. 4 PEACE-3 Study Results: Study Population & Disposition

EP. 5 PEACE-3 Study Results: Efficacy

EP. 5 PEACE-3 Study Results: Efficacy

EP. 6 PEACE-3 Study Results: Safety

EP. 6 PEACE-3 Study Results: Safety

EP. 7 How would therapeutic options change if this patient was asymptomatic?

EP. 7 How would therapeutic options change if this patient was asymptomatic?

EP. 8 Protecting bone health for patients receiving Ra-223 + ARPI combination

EP. 8 Protecting bone health for patients receiving Ra-223 + ARPI combination

EP. 9 Ongoing studies of Ra-223–based combinations

EP. 9 Ongoing studies of Ra-223–based combinations

EP. 10 Ongoing studies of Ra- 223–based combinations

EP. 10 Ongoing studies of Ra- 223–based combinations

What if this patient was symptomatic? What other options might you consider?
What are the caveats around data from the phase 3 ALSYMPCA study of Ra-223 for metastatic castration-resistant prostate cancer (mCRPC)? (eg, conducted in era before introduction of ABI and ENZA)

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