April 28th 2024
During a live Community Case Forum event in partnership with the Tennessee Oncology Practice Society, Pierre Gholam, MD, examined the current state of treatment for patients with hepatocellular carcinoma, looking in particular at what data is available for those with Child-Pugh B and C status who have poorer outcomes and have limited data from prospective clinical trials.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Frontline Atezolizumab and Bevacizumab Meet PFS, OS Endpoints in Phase III HCC Trial
October 21st 2019Atezolizumab and bevacizumab demonstrated a statistically significant improvement in both progression-free survival and overall survival compared with sorafenib in patients with unresectable hepatocellular carcinoma who have not received previous systemic therapy; this met both of the co-primary endpoints of the phase III IMbrave150 trial.
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Using Select Assessment Criteria May Change Prognoses in Advanced HCC
October 19th 2019In an interview with Targeted Oncology at the ILCA conference, Rimola, radiologist, Radiology Department, Barcelona Clinic Liver Cancer Group, University of Barcelona, explained how assessment criteria may change patterns of progression and ultimately change outcomes in patients with advanced HCC treated with nivolumab.
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Challenges Remain in Hepatocellular Carcinoma Surveillance of Patients With NASH
October 17th 2019In an interview with Targeted Oncology, Amit Singal, MD, MS, discussed issues with surveillance in patients with NASH, with or without cirrhosis. He also highlighted how combatting these issues can help improve the survival of patients with NASH-related HCC.
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Choosing Between Systemic Therapy and TACE for HCC
October 11th 2019What is the ideal first-line therapy for nonresectable, non–transplantable eligible, liver-only hepatocellular carcinoma? In a debate at the 2019 Gastrointestinal Oncology Conference, Mark Yarchoan, MD, had the unenviable task of convincing the audience that systemic therapy was the way to go.
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Encouraging Early Data of Atezolizumab/Bevacizumab Leads to Comparative Phase III Study
October 9th 2019In an interview with <em>Targeted Oncology</em>, LMichael S. Lee, MD, discussed the early data on the combination of atezolizumab and bevacizumab in patients with unresectable HCC. He also highlighted the importance of further validation, like the phase III IMbrave150 study, which is comparing the combination to the standard of care.
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Analyzing Real-World Data for CAR T-Cell Therapy in Patients With ALL and DLBCL
October 7th 2019Marcelo C. Pasquini, MD, discusses the rationale for analyzing real-world data for the use of tisagenlecleucel, a chimeric antigen receptor T-cell therapy, as a treatment for patients with acute lymphoblastic leukemia and diffuse large B-cell lymphoma. This CD19 CAR T cell was approved 2 years ago for use in both ALL and DLBCL.
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ASCO Adds Oral Anticoagulants to Venous Thromboembolism Guidelines for Patients With Cancer
October 4th 2019The addition of direct oral oral anticoagulants for the management of venous thromboembolism in patients with cancer is the latest change to previous guidelines issued by the American Society of Clinical Oncology.
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Clinically Meaningful Improvement in TRK Fusion Cancer Detected with Larotrectinib
October 3rd 2019Using a measure known as the growth modulation index, patients with TRK fusion–positive cancers who were treated with larotrectinib had a clinically meaningful improvement in progression-free survival compared with the time to progression on their prior treatment, an analysis of patients enrolled in 1 of 3 clinical trials has found.
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Larotrectinib Maintains Safety and High Efficacy in TRK Fusion-Positive Cancer
September 29th 2019Three clinical trials presented at the 2019 ESMO Congress show that the tropomyosin receptor kinase inhibitor larotrectinib continues to show anti-tumor activity, including long-lasting objective responses and low toxicity, according to results from an integrated analysis.
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Combination of Atezolizumab and Bevacizumab Shows Early Efficacy in Unresectable HCC
September 28th 2019Atezolizumab in combination with bevacizumab induced objective responses in patients with unresectable hepatocellular carcinoma, according to results presented at the 2019 ESMO Congress from 2 small clinical trials.
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Adverse Events Inform Treatment Decisions in HCC for Frontline Lenvatinib Versus Sorafenib
September 25th 2019David J. Pinato, MD, PhD, discusses the approach to selecting the appropriate frontline agent for patients with hepatocellular carcinoma. Sorafenib has been around for many years, but now that lenvatinib is FDA approved as well, physicians can now choose between the 2 agents.
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Annual Hematology Meeting Cochair Encourages Embracing of CAR T-Cell Therapy
September 24th 2019Now in it 24th year, the annual International Congress on Hematologic Malignancies: Focus on Leukemias, Lymphomas, and Myeloma, hosted by Physicians’ Education Resource, LLC, continues to bring significant advances in hematology to the forefront.
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Perioperative Nivolumab/Ipilimumab Combo Showing Early Promising Results in HCC
September 24th 2019Pathologic complete responses were seen in 29% of patients with resectable hepatocellular carcinoma treated with a perioperative immunotherapy regimen in the first interim analysis of a phase II trial, reported Yehia I. Abugabal, MD, in his presentation at the 2019 ILCA Annual Conference.
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Atezolizumab Plus Bevacizumab Offers a Promising Option for Unresectable HCC
September 23rd 2019Clinically meaningful and durable objective responses were observed in the phase Ib subgroup efficacy analysis of atezolizumab plus bevacizumab in patients with previously untreated, unresectable hepatocellular carcinoma.
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Real-Life Analysis Confirms Benefit of Sorafenib/Regorafenib Sequence in HCC
September 23rd 2019In an interview with <em>Targeted Oncology</em>, María Varela, MD, PhD, discussed the rationale of the findings from the real-life analysis and their importance for patients with HCC being treated outside of a clinical trial.
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Second-Line Pembrolizumab Confers Improved OS, PFS in Patients With Advanced HCC
September 22nd 2019The final analysis of KEYNOTE-240, a phase III study of pembrolizumab in advanced hepatocellular cancer, demonstrated favorable benefit in overall survival and progression-free survival, according to Richard S. Finn, MD, during his presentation at the 13th Annual Conference of the International Liver Cancer Association in Chicago.
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Curative and Palliative Treatment Options for Patients With Hepatocellular Carcinoma
September 22nd 2019Amit Singal, MD, discusses the current treatment landscape for patients with hepatocellular carcinoma and how the treatments differ among patients caught in early-stage versus late-stage at the 2019 International Liver Cancer Association Annual Conference.
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RESORCE Trial Analysis Shows Higher AFP Responses Achieved With Regorafenib in HCC
September 22nd 2019Treatment with regorafenib resulted in higher rates of alpha-fetoprotein level response compared with placebo in patients with unresectable hepatocellular carcinoma who had progressed on prior sorafenib, according to an analysis from the phase III RESORCE trial.
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AFP Response Could Assist in Cabozantinib Therapy Selection in HCC
September 22nd 2019Patients with advanced hepatocellular carcinoma treated with cabozantinib had higher alpha-fetoprotein response rates versus those treated with placebo, according to findings of a subanalysis of the phase III CELESTIAL trial.
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Expert Speaks to Non-Alcoholic Fatty Liver Disease-Related Mortality and Development of HCC
September 21st 2019In an interview with <em>Targeted Oncology</em>, Katherine A. McGlynn, PhD, MPH, discussed the population attributable fraction of non-alcoholic fatty liver disease in developing hepatocellular carcinoma, as well as related disorders, in the United States that contribute to the risk of mortality.<br />
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Safety of Nivolumab/Ipilimumab Combination Confirmed for Advanced HCC
September 21st 2019For those with advanced hepatocellular carcinoma, the CheckMate 040 study found that the combination can be effective. Information from that study found that the combination can also yield a favorable safety profile, said Anthony B. El-Khoueiry, MD, in his presentation at the 2019 ILCA Annual Conference.
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Surgical Oncologist Highlights Treatment Approaches for HCC Ahead of ISGIO
September 19th 2019In an interview with <em>Targeted Oncology</em>, Michael A. Choti, MD, discussed what he’s looking forward to at the 2019 ISGIO Annual Conference and why this meeting is so important to physicians in the field of GI oncology. He also highlighted the surgical approaches to treating patients with HCC from his own experiences as a surgical oncologist, as well as the challenges associated with these treatment options.
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