April 29th 2024
Trastuzumab-strf, a biosimilar of trastuzumab, has received FDA approval for treating HER2-overexpressing breast cancer and metastatic gastric cancer.
February 1st 2024
Patient, Provider and Caregiver Connection™: Addressing Patient Concerns During the Treatment and Management of HR+/HER2- Breast Cancer
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Show Me Your Care Plan: Nursing Considerations for Managing Breast Cancer Patients
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Community Practice Connections™: The Newest Frontier in HR+ Breast Cancer—Targeting ESR1 Mutations with Next-Generation Endocrine Therapy
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Clinical Case Vignette Series™: 40th Annual Miami Breast Cancer Conference®
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Oncology Consultations®: Next Generation SERDs—Key Data and Practical Takeaways for the Community Physician
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HER2+ Breast Cancer Tumor Board: Navigating Current and Evolving Strategies from Early Stages to Metastases
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Medical Crossfire®: Leveraging Multidisciplinary Teams in Early–Stage Breast Cancer When the Goal is Cure
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Show Me the Data®: Do We Have Sea Change for Novel Approaches in HR+/HER2- Breast Cancer? CDK, PI3K/AKT, ADC, and Next-Gen SERD Strategies Assessed
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Multidisciplinary Management of TNBC: Immunotherapy, PARP, TROP2, Oh My!
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23rd Annual International Congress on the Future of Breast Cancer® West
July 12-13, 2024
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23rd Annual International Congress on the Future of Breast Cancer® East
July 19-20, 2024
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Community Practice Connections™: The Advent of TROP2-Targeted Treatment Approaches in HR+/HER2- Breast Cancer
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Show Me the Data™: Do We Have Sea Change for Novel Approaches in HR+/HER2- Breast Cancer? CDK, PI3K/AKT, ADC, and Next-Gen SERD Strategies Assessed
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Community Practice Connections™: Controversies and Conversations About HER2- Expressing Breast Cancer…Advances in Management of HER2-Low to -Positive Disease
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Cancer Summaries and Commentaries™: Clinical Updates from Chicago in Breast Cancer
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Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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Community Practice Connections™: Leveraging Multidisciplinary Teams in Early-Stage Breast Cancer When the Goal Is Cure
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Community Practice Connections®: Evaluating the Evolving Treatment Landscape for mHR+ Breast Cancer-How to Personalize Care and Improve Patient Outcomes
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Community Practice Connections™: 22nd Annual International Congress on the Future of Breast Cancer®
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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22nd Annual School of Breast Oncology
November 7-9, 2024
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42nd Annual CFS®: Innovative Cancer Therapy for Tomorrow®
November 13-15, 2024
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Emerging Treatments and Evolving Paradigms in HER2-Low Breast Cancer
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Matching the Right Patients to the Right Therapies in TNBC: Case-Based Applications of Immune Checkpoint Inhibitors, PARP Inhibitors, and TROP2-Targeted ADCs
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Clinical Vignettes™: The Experts Explain How They Integrate PET Imaging into Metastatic HR+ Breast Cancer Care Settings
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Matching the Right Patients to the Right Therapies in TNBC: Case-Based Applications of Immune Checkpoint Inhibitors, PARP Inhibitors, and TROP2-Targeted ADCs
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School of Breast Oncology® Live Video Webcast: Clinical Updates from San Antonio
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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HER2CLIMB Study Shows Efficacy in HER2 Breast Cancer With Brain Metastases
July 1st 2020Nancy U. Lin, MD, discusses the latest findings from the HER2CLIMB study of either tucatinib or placebo, added to trastuzumab and capecitabine, for patients with previously treated HER2-positive metastatic breast cancer who have brain metastases.
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Abemaciclib Triplet Improve PFS in HR+, HER+ Advanced Breast Cancer
June 10th 2020"The endocrine combination of abemaciclib plus fulvestrant and trastuzumab showed significant improvements in both progression-free survival and overall response compared with chemotherapy plus trastuzumab and was generally well-tolerated."
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HER2 FISH Ratio May Predict Anti-HER2 Response Without Chemo in HER2+ Breast Cancer
June 10th 2020“While the sample size and power are limited, these results suggest that a higher HER2 FISH ratio at baseline core biopsy may be a potential biomarker to select patients for neoadjuvant dual anti-HER2 therapy without chemotherapy."
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PFS Data Support Approval of Fam-Trastuzumab Deruxtecan-nxki for HER2+ Breast Cancer
June 1st 2020Yeon Hee Park, MD, discusses the data supporting the FDA’s accelerated approval of fam-trastuzumab deruxtecan-nxki for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received ≥2 prior anti–HER2-based regimens in the metastatic setting.
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The addition of tucatinib to treatment with trastuzumab and capecitabine resulted in more than a 60% reduction in the risk of central nervous system progression or death in both patients with previously treated HER2-positive metastatic breast cancer who have active or stable brain metastases.
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FDA Cancels ODAC Meeting for BLA of Margetuximab in HER2+ Breast Cancer
May 28th 2020"Since submitting the BLA for margetuximab, we have worked collaboratively with the FDA to answer the Agency’s questions as they arise. We will continue to work closely with the Agency to potentially bring margetuximab as a treatment option to patients with HER2-positive metastatic breast cancer."
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Pertuzumab Added to Trastuzumab and Chemotherapy Improves Survival in HER2+ Breast Cancer
May 9th 2020"HER2-targeted therapy has changed the natural history of HER2-positive metastatic breast cancer, with the dual blockade of pertuzumab and trastuzumab, with docetaxel, demonstrating an 8-year landmark overall survival rate of 37%."
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TCbHP/T-DM1+P Sequence Shows Promise in HER2+ Primary Breast Cancer
May 4th 2020A new phase II trial showed higher pathological complete response rates in patients with HER2-positive breast cancer who took docetaxel, carboplatin, trastuzumab, and pertuzumab followed by trastuzumab emtansine, and pertuzumab, versus those who took only the former therapy.
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Survival Improved With the Addition of Chemotherapy for Small HER2-Positive Breast Cancer
April 23rd 2020"We know that, in general, patients with this particular subset of hormone-receptor-positive breast cancers should get chemotherapy, but all the studies showing the benefits of chemotherapy included patients with large cancers."
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Talazoparib Toxicities Manageable in gBRCA-Mutated HER2-Negative Advanced Breast Cancer
April 20th 2020Safety data from the phase III EMBRACA trial were recently published. Talazoparib appears to be safe with manageable toxicities in patients with germline BRCA-mutated HER2-negative advanced breast cancer.
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Women With Indigenous American Ancestry Have Higher Odds of HER2-Positive Breast Cancer
April 8th 2020Indigenous American ancestry has been linked to an increased incidence of HER2-positive breast cancer, according to the Peruvian Genetics and Genomics of Breast Cancer Study study published in Cancer Research.
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Platinum Chemotherapy Nonsuperior to Standard Chemotherapy in HER2-Negative Breast Cancer
March 7th 2020Despite evidence from previous studies that showed that platinum-based chemotherapy agents are active in patients with breast cancer, platinum-based chemotherapy was not found to be superior to standard chemotherapy in terms of eliciting pathologic complete responses in patients with HER2-negative breast cancer carrying a BRCA mutation, according to data from the INFORM trial published in the Journal of Clinical Oncology.
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Subcutaneous Pertuzumab Plus Trastuzumab May Optimize Treatment of HER2+ Breast Cancer
January 7th 2020In an interview with Targeted Oncology at the 2019 San Antonio Breast Cancer Conference, Antionette Tan, MD, shared the results of the FeDEriCa study and explained how the results can impact the treatment of patients with HER2-positive breast cancer in the clinical setting.
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European Regulators Approve Adjuvant T-DM1 for Treatment of Patients With HER2+ Breast Cancer
December 31st 2019Ado-trastuzumab emtansine has been approved by the European Commission for the treatment of adult patients with HER2-positive early breast cancer, in the adjuvant setting who have residual invasive disease after taxane-based chemotherapy and HER2-targeted therapy, in the neoadjuvant setting.<sup>1</sup>
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Tucatinib Developer Seeks FDA Approval for the Treatment of HER2-Positive Breast Cancer
December 23rd 2019Tucatinib developer, Seattle Genetics, Inc., has submitted a new drug application to the FDA for tucatinib in combination with trastuzumab and capecitabine for the treatment of patients with advanced unresectable or metastatic HER2-positive breast cancer, including those with brain metastases, who have received at least 3 prior HER2-directed drugs alone or in combination with other drugs, in the neoadjuvant, adjuvant, or metastatic setting, according to a press release.<br />
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Adjuvant T-DM1 Leads to Low Recurrence Rates in Patients With Early HER2+ Breast Cancer
December 12th 2019High rates of disease control were reported in the first set of results from a randomized trial in which adjuvant T-DM1 was compared to trastuzumab and paclitaxel for the treatment of patients with early HER2-positive breast cancer.
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Adjuvant Pertuzumab Regimen Improves OS in Patients With HER2+ Early Breast Cancer
December 12th 2019In the phase III APHINITY trial, pertuzumab with trastuzumab plus chemotherapy demonstrated a 0.9% improvement in overall survival and continued to reduce the risk of disease recurrence in patients with HER2-positive early breast cancer in the adjuvant setting, according to a 6-year analysis of the phase III APHINITY trial presented at the 2019 San Antonio Breast Cancer Symposium.
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Later-Line Management of Metastatic Triple Negative Breast Cancer
November 27th 2019Triple-negative breast cancer — defined as tumors that lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 amplification— is a heterogenous disease and clinically represents a major unmet need in the field of oncology. TNBC is associated with aggressive tumor biology and higher risk of recurrence and visceral metastasis, including brain metastasis.
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Expert Highlights Emerging Agents for Metastatic HER2+ Breast Cancer
September 16th 2019In an interview with Targeted Oncology, Charles Geyer, MD, discussed the potential role of neratinib as well as other new agents that are coming down the pipeline for the treatment of patients with metastatic HER2-positive breast cancer. He also addressed the biggest challenges oncologists face in managing this disease.
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Explaining PFS2 in the MONALEESA-7 Trial for HR+/HER2- Breast Cancer
July 3rd 2019Debu Tripathy, MD, of the Department of Breast Medical Oncology, Division of Cancer Medicine, MD Anderson Cancer Center, was an investigator in the phase III MONALEESA-7 trial. The purpose of the study was to examine how endocrine therapy, in combination with a cyclin-dependent kinase inhibitor, affects progression-free survival and overall survival in premenopausal patients with HR-positive, HER2-negative advanced breast cancer.
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