LUNG CANCER

Due to an active research landscape, the National Comprehensive Cancer Network Guidelines for non–small cell lung cancer have had 3 recent updates that include numerous clinically relevant recommendations.

Julie R. Brahmer, MD, discusses data for atezolizumab plus platinum/etoposide versus platinum/etoposide alone in patients with small cell lung cancer in the IMpower133 trial.

Edward B. Garon, MD, discusses the role of EGFR-targeted therapies in the treatment landscape of NSCLC.

A look back at all the FDA news in oncology from the month of February 2019, including several new approvals, priority review designations, and an orphan drug desgination.

Guardant360—a 73-gene next-generation sequencing panel—detected all of the guideline-recommended biomarkers in patients newly diagnosed with metastatic non–small cell lung cancer at a similar rate, but in a faster turnaround time than tissue genotyping, according to data from the NILE study.

Stage IIIB Unresectable NSCLC After Chemoradiotherapy

Stage IIIA Unresectable NSCLC After Chemoradiotherapy

Pembrolizumab has been granted a priority review designation by the FDA for the treatment of patients with advanced small cell lung cancer whose disease has progressed following ≥2 prior lines of therapy.

Entrectinib has been granted a priority review designation by the FDA as a therapy for&nbsp;select adult and pediatric patients with <em>NTRK</em> fusion&ndash;positive locally advanced or metastatic solid tumors, as well as patients with metastatic <em>ROS1</em>-positive non&ndash;small cell lung cancer, according to Genentech, the developer of the multikinase inhibitor.