Riess case 4:
52-year-old man with relapsed metastatic NSCLC.
- 52-year-old man developed NSCLC, metastatic to the bone and brain
- Was found to have an EGFR activating mutation
- Started on erlotinib with a good response, received radiotherapy to hip and brain
- After 12 months he developed cough and dyspnea on exertion
- CT scan showed progression in the primary lesion and multiple other pulmonary nodules
- Tissue biopsy showed an EGFR T790M mutation
- Subsequent treatment with osimertinib resulted in tumor shrinkage as well as resolution of his symptoms.