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Opinion|Videos|January 12, 2026

Exploring Combination Therapy in Newly Diagnosed cGVHD

Author(s)Leyla O. Shune, MD

Leyla O. Shune, MD, discusses results from an interim safety analysis of a randomized phase 2 study exploring axatilimab in combination with ruxolitinib in patients with newly diagnosed chronic graft-versus-host disease.

Episodes in this series

Experts featured in this series.

EP. 1 Treatment Challenges and Solutions in cGVHD

Experts featured in this series.

EP. 2 Available Treatments and Results in Steroid Refractory/Dependent cGVHD

Experts featured in this series.

EP. 3 Real-World Tolerability and Safety Results for Axatilimab in cGVHD

Experts featured in this series.

EP. 4 Exploring Combination Therapy in Newly Diagnosed cGVHD

Leyla O. Shune, MD, discusses results from an interim safety analysis of a randomized phase 2 study exploring axatilimab in combination with ruxolitinib in patients with newly diagnosed chronic graft-versus-host disease. She explains how the results, which were presented at the 2025 ASH Annual Meeting, showed that no new safety signals emerged when combining the 2 agents compared with previously reported outcomes for single-agent use of the treatments.

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