Opinion|Videos|December 22, 2025

Treatment Challenges and Solutions in cGVHD

Author(s)Leyla O. Shune, MD

Addressing Treatment Challenges in Chronic Graft-Versus-Host Disease

Episodes in this series

Experts featured in this series.

EP. 1 Treatment Challenges and Solutions in cGVHD

Experts featured in this series.

EP. 2 Available Treatments and Results in Steroid Refractory/Dependent cGVHD

Experts featured in this series.

EP. 3 Real-World Tolerability and Safety Results for Axatilimab in cGVHD

Experts featured in this series.

EP. 4 Exploring Combination Therapy in Newly Diagnosed cGVHD

Experts featured in this series.

EP. 5 Sequencing in the cGVHD Treatment Paradigm

Experts featured in this series.

EP. 6 Future Directions in cGVHD Treatment

Leyla O. Shune, MD, discusses the challenge of managing patients with heavily pretreated chronic graft-versus-host disease (cGVHD) and explains the significance of targeting the underlying profibrotic pathways. She highlights the emergence of axatilimab, a CSF-1R inhibitor that attacks the underlying mechanisms of cGVHD by targeting proinflammatory and profibrotic monocytes and macrophages.

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