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Opinion|Videos|March 27, 2025

First-Line Therapy for Advanced HCC: The Role of TKIs and ICIs

Panelists discuss how current first-line systemic therapies for advanced hepatocellular carcinoma (HCC) include atezolizumab + bevacizumab and durvalumab + tremelimumab, replacing tyrosine kinase inhibitors (TKIs) like sorafenib and lenvatinib. Emerging combinations with anti–PD-L1 agents enhance efficacy. TKI + immune checkpoint inhibitor (ICI) combinations offer synergistic benefits but pose toxicity, cost, and biomarker challenges.

Episodes in this series

Video content above is prompted by the following:

  • Briefly discuss current approved first-line systemic therapies for advanced HCC.
  • How are emerging combination strategies, particularly with anti–PD-L1 agents, reshaping the first-line treatment landscape?
  • What are the potential advantages of TKI + ICI combinations compared with TKI monotherapy?
  • Please also discuss potential challenges.

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