Opinion|Videos|March 20, 2025
Navigating the Evolving First-Line Treatment Regimens in Intermediate-Stage HCC
Author(s)Richard S. Finn, MD, Amit Singal, MD
Panelists discuss how the role of systemic therapy in intermediate-stage hepatocellular carcinoma (HCC) is evolving with combinations like immunotherapy and targeted agents enhancing locoregional treatment. LEAP-012 and EMERALD-1 evaluate lenvatinib + pembrolizumab and durvalumab-based regimens with transarterial chemoembolization (TACE), respectively. Their findings may redefine treatment paradigms, improving outcomes and expanding therapeutic options.
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Video content above is prompted by the following:
- How might the role of systemic therapy evolve in the management of intermediate-stage HCC?
- Please review and discuss the data from LEAP-012 and EMERALD-1.
- As you review data, what are the clinical implications of these results?
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