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Opinion|Videos|April 3, 2025

The Evolving Role of Lenvatinib in the HCC Therapeutic Landscape

Author(s)Richard S. Finn, MD, Amit Singal, MD

Panelists discuss how lenvatinib has significantly impacted the systemic therapy landscape for hepatocellular carcinoma (HCC) across different stages. As a first-line treatment, it offers a viable alternative to sorafenib, demonstrating noninferior overall survival with improved progression-free survival and response rates. Its role extends to combination regimens and advanced-stage disease management.

Episodes in this series

2 experts in this video

EP. 1 Current Treatment Practices in Embolization-Eligible HCC

2 experts in this video

EP. 2 When to Move Beyond TACE: The Expanding Role of Systemic Therapy in Intermediate-Stage HCC

2 experts in this video

EP. 3 Navigating the Evolving First-Line Treatment Regimens in Intermediate-Stage HCC

2 experts in this video

EP. 4 Considerations for Treatment Approaches in Intermediate-Stage HCC

2 experts in this video

EP. 5 First-Line Therapy for Advanced HCC: The Role of TKIs and ICIs

2 experts in this video

EP. 6 Lenvatinib in Advanced HCC: Considerations for Monotherapy and Combination Regimens

2 experts in this video

EP. 7 Second-Line Therapy in Advanced HCC: Treatment Considerations and Evolving Options

2 experts in this video

EP. 8 The Evolving Role of Lenvatinib in the HCC Therapeutic Landscape

Video content above is prompted by the following:

How has lenvatinib impacted the systemic therapy landscape for HCC across different stages?

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