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Opinion|Videos|March 11, 2025

When to Move Beyond TACE: The Expanding Role of Systemic Therapy in Intermediate-Stage HCC

Author(s)Richard S. Finn, MD, Amit Singal, MD

Panelists discuss how combining systemic therapy with locoregional treatments like transarterial chemoembolization (TACE) aims to enhance therapeutic efficacy by addressing its limitations, such as incomplete tumor necrosis and hypoxia-induced progression. Tyrosine kinase inhibitors (TKIs) like lenvatinib and immune checkpoint inhibitors (ICIs) counteract TACE-induced resistance by inhibiting angiogenesis and boosting immune response, improving overall tumor control.

Episodes in this series

2 experts in this video

EP. 1 Current Treatment Practices in Embolization-Eligible HCC

2 experts in this video

EP. 2 When to Move Beyond TACE: The Expanding Role of Systemic Therapy in Intermediate-Stage HCC

2 experts in this video

EP. 3 Navigating the Evolving First-Line Treatment Regimens in Intermediate-Stage HCC

2 experts in this video

EP. 4 Considerations for Treatment Approaches in Intermediate-Stage HCC

2 experts in this video

EP. 5 First-Line Therapy for Advanced HCC: The Role of TKIs and ICIs

2 experts in this video

EP. 6 Lenvatinib in Advanced HCC: Considerations for Monotherapy and Combination Regimens

2 experts in this video

EP. 7 Second-Line Therapy in Advanced HCC: Treatment Considerations and Evolving Options

2 experts in this video

EP. 8 The Evolving Role of Lenvatinib in the HCC Therapeutic Landscape

Video content above is prompted by the following:

In recent years, several trials have sought to evaluate the potential synergy of combining systemic therapy with locoregional therapy. Please discuss the rationale for combining systemic therapy with locoregional treatments like TACE.
What are the limitations of TACE monotherapy?
How do TKIs like lenvatinib or ICIs contribute to overcoming TACE-induced tumor progression/resistance mechanisms?
How does this combination potentially enhance treatment efficacy compared with TACE alone?

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