Metastatic Non-Small Cell Lung Cancer with Alexander Drilon, MD: Case 2

Case Scenario 2:

SR is a 58 year-old female, former smoker 20 PPY (stopped smoking 5 years ago), presents with cough and SOB. She experienced an unintended 10 lb weight loss over a 3-month period.

• Tissue analysis identified adenocarcinoma, EGFR, ALK, ROS1 negative.
• PD-L1 expression was < 50%.
• Patient has stage IV disease with metastasis to the liver.
• A chest CT scan confirmed the primary mass in the upper lobe of the right lung, with several pleural metastases and malignant pleural effusion.
• MRI of the brain was negative for intracranial metastases.
• Patient has not complained of blood in the sputum.
• Patient has history of well controlled HTN.
• Her performance status was 1 at diagnosis.

Patient was started on carboplatin/paclitaxel/bevacizumab for 4 cycles. Patient showed partial response and was continued on bevacizumab until progression.