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Opinion|Videos|January 2, 2025

Newly Diagnosed mHSPC: Androgen Receptor Pathway Inhibitor Selection

Author(s)Evan Y. Yu, MD

Evan Y. Yu, MD, discusses how individualized first-line systemic therapy selection for metastatic hormone-sensitive prostate cancer (mHSPC) involves considering factors such as disease burden, patient performance status, and comorbidities while weighing the pros and cons of current options—such as chemotherapy-sparing regimens, androgen receptor pathway inhibitor (ARPI) selection, and the use of triplet versus doublet combination therapies—to optimize efficacy and minimize adverse effects based on each patient’s unique clinical profile.

Episodes in this series

EP. 1 Introduction & Case 1 Presentation: mHSPC

EP. 1 Introduction & Case 1 Presentation: mHSPC

EP. 2 Newly diagnosed Diagnosed mHSPC: Goals of Therapy

EP. 2 Newly diagnosed Diagnosed mHSPC: Goals of Therapy

EP. 3 Newly Diagnosed mHSPC: First-Line Treatment Options

EP. 3 Newly Diagnosed mHSPC: First-Line Treatment Options

EP. 4 Newly Diagnosed mHSPC: Androgen Receptor Pathway Inhibitor Selection

EP. 4 Newly Diagnosed mHSPC: Androgen Receptor Pathway Inhibitor Selection

EP. 5 Case 1 Presentation (cont): mHSPC

EP. 5 Case 1 Presentation (cont): mHSPC

EP. 6 Phase 3 ARANOTE Study of ADT + Darolutamide

EP. 6 Phase 3 ARANOTE Study of ADT + Darolutamide

EP. 7 Phase 3 ARANOTE Study of ADT + Darolutamide: Safety

EP. 7 Phase 3 ARANOTE Study of ADT + Darolutamide: Safety

EP. 8 mHSPC: Applying Data Toward Treatment Decision-Making

EP. 8 mHSPC: Applying Data Toward Treatment Decision-Making

EP. 9 Adding Chemotherapy for a Patient Receiving ADT + an ARPI

EP. 9 Adding Chemotherapy for a Patient Receiving ADT + an ARPI

EP. 10 Case 2 Presentation: mCRPC

EP. 10 Case 2 Presentation: mCRPC

Video content above is prompted by the following:

Please discuss how you approach individualized first-line systemic therapy selection for patients with metastatic hormone-sensitive prostate cancer (mHSPC).
1. Please offer perspectives on pros/cons of current options for first-line therapy.
2. What factors do you consider during treatment decision-making (eg, use of chemotherapy-sparing regimens, ARPI selection, triplet versus doublet combination systemic therapy)?

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