Opinion|Videos|January 2, 2025

Newly Diagnosed mHSPC: First-Line Treatment Options

Author(s)Evan Y. Yu, MD

Evan Y. Yu, MD, discusses how systemic therapy options for newly diagnosed metastatic hormone-sensitive prostate cancer include androgen deprivation therapy (ADT) combined with chemotherapy or androgen receptor pathway inhibitors (ARPIs) such as abiraterone or enzalutamide, with the choice of frontline treatment depending on factors such as disease burden and patient characteristics, while also considering the structural and physical differences between these ARPIs, which may influence their efficacy and adverse effect profiles.

Episodes in this series

EP. 1 Introduction & Case 1 Presentation: mHSPC

EP. 1 Introduction & Case 1 Presentation: mHSPC

EP. 2 Newly diagnosed Diagnosed mHSPC: Goals of Therapy

EP. 2 Newly diagnosed Diagnosed mHSPC: Goals of Therapy

EP. 3 Newly Diagnosed mHSPC: First-Line Treatment Options

EP. 3 Newly Diagnosed mHSPC: First-Line Treatment Options

EP. 4 Newly Diagnosed mHSPC: Androgen Receptor Pathway Inhibitor Selection

EP. 4 Newly Diagnosed mHSPC: Androgen Receptor Pathway Inhibitor Selection

EP. 5 Case 1 Presentation (cont): mHSPC

EP. 5 Case 1 Presentation (cont): mHSPC

EP. 6 Phase 3 ARANOTE Study of ADT + Darolutamide

EP. 6 Phase 3 ARANOTE Study of ADT + Darolutamide

EP. 7 Phase 3 ARANOTE Study of ADT + Darolutamide: Safety

EP. 7 Phase 3 ARANOTE Study of ADT + Darolutamide: Safety

EP. 8 mHSPC: Applying Data Toward Treatment Decision-Making

EP. 8 mHSPC: Applying Data Toward Treatment Decision-Making

EP. 9 Adding Chemotherapy for a Patient Receiving ADT + an ARPI

EP. 9 Adding Chemotherapy for a Patient Receiving ADT + an ARPI

EP. 10 Case 2 Presentation: mCRPC

EP. 10 Case 2 Presentation: mCRPC

Video content above is prompted by the following:

What systemic therapy options would you discuss with this patient?
1. Which do you consider for frontline treatment?
2. Thinking about the individual ARPI used in this setting, what are their similarities and differences in terms of structural formula and physical properties?

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