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Opinion|Videos|April 21, 2025

Ruxolitinib Therapy for cGVHD: Insights on Patient and Safety Monitoring

Author(s)Nelson Chao, MD, MBA

A panelist discusses how managing adverse events (AEs) in patients with chronic graft-vs-host disease (cGVHD) treated with ruxolitinib requires a structured monitoring approach that balances therapeutic efficacy with patient safety through regular clinical evaluations, laboratory assessments, and proactive management strategies tailored to individual risk profiles.

Episodes in this series

1 expert is featured in this series.

EP. 1 Clinical Case – A Patient With Steroid-Refractory cGVHD

1 expert is featured in this series.

EP. 2 Current Practices and Initial Treatment Considerations for Patients With cGVHD

1 expert is featured in this series.

EP. 3 Long-Term Outcomes of Ruxolitinib Therapy in Patients With cGVHD

1 expert is featured in this series.

EP. 4 Ruxolitinib Therapy for cGVHD: Insights on Patient and Safety Monitoring

1 expert is featured in this series.

EP. 5 The Treatment Landscape for cGVHD: From Current Practices to Evolving Therapies

1 expert is featured in this series.

EP. 6 Academic Perspectives and Key Considerations for Optimal Patient Care in cGVHD

Video content above is prompted by the following:

How do you monitor and mitigate AEs in patients with cGVHD treated with ruxolitinib?
What are the key signs to monitor?
How does the risk of infection change your treatment approach?
When do you consider dose modifications or treatment discontinuation?
What is your approach to patient education when treating steroid-refractory cGVHD?
Please discuss how treatments impact quality of life and share strategies to keep patients informed about, eg, disease response and symptoms to look out for.

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