Opinion|Videos|April 28, 2025

The Treatment Landscape for cGVHD: From Current Practices to Evolving Therapies

Author(s)Nelson Chao, MD, MBA

A panelist discusses how the treatment landscape for chronic graft-vs-host disease (cGVHD) has evolved significantly in recent years, with several pivotal clinical trials beyond REACH3 informing our approach, including the REACH1 and REACH2 trials for acute GVHD; the ROCKstar trial supporting belumosudil approval; and studies evaluating ibrutinib, axatilimab, and extracorporeal photopheresis.

Episodes in this series

1 expert is featured in this series.

EP. 1 Clinical Case – A Patient With Steroid-Refractory cGVHD

1 expert is featured in this series.

EP. 2 Current Practices and Initial Treatment Considerations for Patients With cGVHD

1 expert is featured in this series.

EP. 3 Long-Term Outcomes of Ruxolitinib Therapy in Patients With cGVHD

1 expert is featured in this series.

EP. 4 Ruxolitinib Therapy for cGVHD: Insights on Patient and Safety Monitoring

1 expert is featured in this series.

EP. 5 The Treatment Landscape for cGVHD: From Current Practices to Evolving Therapies

1 expert is featured in this series.

EP. 6 Academic Perspectives and Key Considerations for Optimal Patient Care in cGVHD

Video content above is prompted by the following:

Please review the treatment landscape; how do other trials inform treatment?
What other treatment strategies are available?
Which patients do you think are best suited to receive ruxolitinib therapy?
Where do you think the future of cGVHD treatment is heading?

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