|Videos|August 6, 2014

Strategies for Overcoming <em>KRAS</em> Mutations in Lung Cancer

David Gandara, MD, professor, Division of Hematology/Oncology, University of California Davis Comprehensive Cancer Center, discusses overcoming KRAS mutations in lung cancer.

Clinical Pearls

David Gandara, MD, professor, Division of Hematology/Oncology, University of California Davis Comprehensive Cancer Center, discusses overcomingKRASmutations in lung cancer. Gandara presented on this topic at the15th Annual International Lung Cancer Congress®.

KRASmutations tend to predict less response to chemotherapy or TKIs.
It has been extremely difficult to develop drugs that directly inhibit KRAS.
MEK inhibitors in combination with chemotherapy have shown downstream activity.
SWOG 1408 will test this hypothesis with a MEK inhibitor (trametinib) in combination with chemotherapy (docetaxel) or an AKT inhibitor (GSK795).

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