Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|September 8, 2014
The Potential Benefit for a Blood-Based Test to Detect a T790M Mutation
Paul A. Bunn, Jr., MD, Giant of Cancer Care: Lung Cancer, professor of medicine in medical oncology, head of the division of medical oncology, University of Colorado, discusses the potential benefit for a blood-based test to detect a T790M mutation in lung cancer.
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Clinical Pearls
Paul A. Bunn, Jr., MD, Giant of Cancer Care: Lung Cancer, professor of medicine in medical oncology, head of the division of medical oncology, University of Colorado, discusses the potential benefit for a blood-based test to detect a T790M mutation in lung cancer.
- EGFR TKIs work extremely well in patients withEGFR-mutated lung cancer, but unfortunately, they are not curative. About 50% of the time, the cancer becomes resistant and develops aT790Mmutation.
- Most patients withT790M-mutated lung cancer will secrete DNA with that mutation into the blood. Oftentimes, the DNA is secreted into the blood before the tumor is large enough to biopsy.
- A blood- based test could help discover recurrence sooner.
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